CXCL12 and neoplasm: The CXCL12–CXCR4 signaling axis plays a critical role in regulating immune cell trafficking, tumor immune evasion, and the establishment of an immunosuppressive TME.[38] In the context of GC, activation of this pathway has been shown to promote tumor cell survival, migration, and proliferation; while, concurrently suppressing anti‐tumor immune responses.[23, 39] By selectively targeting and inhibiting this pathway, the present study demonstrated significant enhancement of M1‐type TAM polarization, which is closely associated with the initiation of robust anti‐tumor immunity.