Flow cytometry results revealed that compared to the oe‐NC group, the number of T cells and B cells was significantly increased in the tumor tissues of mice in the oe‐NC+M2pep‐Cs NPs/Plerixafor group; while, in the oe‐CXCR4 group, the number of T cells and B cells was significantly decreased. Here, CXCR4 is linked to neoplasm.