Machine learning techniques were instrumental in identifying CXCL12, the principal ligand of CXCR4 (also known as stromal cell‐derived factor 1 or SDF‐1).[35] The CXCL12–CXCR4 axis plays a pivotal role in diverse physiological and pathological processes, including immune regulation, hematopoiesis, inflammation, and cancer metastasis.[36] GO and KEGG enrichment analyses further supported the immune relevance of the differential genes identified in this study. Here, CXCR4 is linked to cancer.