RT‐qPCR results showed that compared to the oe‐NC group, the mRNA expression levels of CXCR4 and CXCL12 in the tumor tissues of the oe‐NC+M2pep‐Cs NPs/Plerixafor group remained unchanged; while, CXCR4 mRNA expression was significantly upregulated in the tumor tissues of the oe‐CXCR4 group, with no change in CXCL12 mRNA expression. Here, CXCR4 is linked to neoplasm.