IL4 and neoplasm: These cells secrete pro‐inflammatory and pro‐angiogenic factors that enhance tumor cell proliferation, invasion, and metastasis.[33] Further, M2 MΦ contributes to the establishment of an immunosuppressive TME, thereby attenuating anti‐tumor immune responses and facilitating disease advancement.[34] To assess the targeting efficiency of M2pep‐Cs NPs/Plerixafor NPs toward MΦ subtypes, THP‐1 monocytes were differentiated into macrophages using PMA and further polarized into M2 MΦ through treatment with IL‐4 and IL‐13.