Considering that ablation of the TP53‐SAT1 signaling pathway did not fully abolish L14‐8‐induced cell growth inhibition, we supposed that other targets and mechanisms of L14‐8 are also involved in the anti‐tumor effects of L14‐8, for example, the induction of apoptosis as we observed in the p53‐deficient PC3 cells, while further studies are needed. The gene discussed is TP53; the disease is neoplasm.