NLRX1 and cancer: The data are suggestive for that the presence of NLRX1 functioning as a brake in energy turnover, which may not be tissue specific, as increased oxygen consumption in hepatocyte cells[35], increased activity of complex I and complex III in cancer cells[67], increased OXPHOS by regulating mitochondrial genome encoded transcripts for key components of complex I and complex IV[68], and increased OXPHOS in renal epithelial cells[72] were all observed with deletion of NLRX1.