INS and Hyperglycemia: A result in alignment with the reported effect of red RBE on enhancing pancreatic structure in n mice treated with a high-fat diet (Munkong et al. 2022) and reinforced by the role of pioglitazone PPARγ agonistic effect in shielding pancreatic β-cells from the effects of hyperglycemia, deficiencies in insulin secretion, and the impact of cell death.