Compared with pMF-ICCs, bMF-ICCs showed more frequent CEA ≥ 5 μg/L (p = 0.01), microvascular invasion (p < 0.001), lymph node metastasis (p < 0.001), bile duct invasion (p < 0.001) and high Ki-67 expression (p = 0.01). This evidence concerns the gene CEACAM5 and metastatic malignant neoplasm in the lymph nodes.