Liver injury, inflammation, and fibrosis further promote pathogenesis of NASH and HCC.[23] Upon examining published GEO datasets (GSE126848,[24] GSE135251,[25] GSE119340,[26]) we observed a reduction in YTHDC1 mRNA levels in both human samples and mouse models of NASH (Figure S7a–c, Supporting Information), suggesting that YTHDC1 is associated with NASH. To investigate whether hepatocyte‐specific deletion of Ythdc1 promotes NASH, Ythdc1‐HKO, and Ythdc1flox/flox mice were fed a methionine‐ and choline‐deficient diet (MCD) for 10 days. The gene discussed is YTHDC1; the disease is metabolic dysfunction-associated steatohepatitis.