METTL3 and hepatocellular carcinoma: Our current and previous studies demonstrate that the deficiency of Ythdc1, Mettl3, or Wtap in the liver leads to liver injury and inflammation,[8, 20] contributing to the pathogenesis of NASH and HCC,[7, 8, 21, 31] indicating that maintaining the expression or activity of YTHDC1, METTL3, and WTAP by small molecules or genetic methods might be an approach to ameliorate liver injury and NASH.