Deubiquitinase OTULIN has been known to negatively regulate M1‐linked polyubiquitin signaling through removing the ubiquitin chains conjugated by LUBAC, and OTULIN deficiency could cause OTULIN‐related autoinflammatory syndrome (ORAS) in humans,[44] indicating a critical role of OTULIN in maintaining immune homeostasis. This evidence concerns the gene OTULIN and autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive.