Immunofluorescence assay and immunoblot analysis demonstrated that OTULIN colocalized with STING in Golgi apparatus upon virus infection, and the overexpression of wild‐type OTULIN decreased the localization of STING in Golgi apparatus following cGAMP stimulation, while the knockout of OTULIN enhanced the localization of STING in Golgi apparatus (Figure S7B–G, Supporting Information). Here, OTULIN is linked to viral infectious disease.