Appropriately controlled STING‐mediated immune responses are beneficial for the host defense against invading pathogens, whereas excessive STING‐dependent inflammatory responses could lead to serious tissue damage and induce inflammatory‐related diseases, such as STING‐associated vasculopathy.[67, 68] Here, we reveal a linear ubiquitination‐governed spatiotemporal regulatory mechanism that fine‐tunes STING‐driven antiviral immunity, which provides a potential therapeutic strategy against infectious diseases via targeting STING. The gene discussed is STING1; the disease is vascular disorder.