The in vivo condition also strongly induced genes related to neural stem cell biology, tumor‐propagation, and GBM stemness, including SOX2, OLIG2, CD133, GFAP, MAP2, NESTIN, FUT4, KLF4, LICAM, CD44, as well as tyrosine kinase receptors (EGFR, PDGFRA), all of which were not induced in 3D GAPE condition, highlighting a remaining gap between in vivo and in vitro paradigms (Figure 5e). This evidence concerns the gene KLF4 and glioblastoma.