DNASE1 and stroke disorder: DNase I was encapsulated in sialic acid‐modified nanoparticles and effectively hitchhiked on neutrophils across the blood‐brain barrier into the injured brain parenchyma after intravenous injection.[11] Coincidentally, M2‐type macrophage extracellular derived vesicles were used to encapsulate DNase I and endow it with the ability to cross the BBB.[12] But these delivery strategies follow the design of conventional brain‐targeted delivery systems for stroke treatment while ignoring the unique physiological location of NETs that distinguishes them from other molecular events.