MPO and ischemia: Myeloperoxidase (MPO) and Neutrophil elastase (NE) are two typical NETs proteases, which degrade extracellular matrix and tight junctions, damage endothelial cells, and trigger inflammatory cascades.[8] The network DNA acts as a microthrombus skeleton, capturing other blood cells and forming immunothrombosis.[9] NETs play an indispensable role in mediating thrombolytic resistance, exacerbating ischemia‐reperfusion injury, and inducing hemorrhagic transformation, and recurrence.[10] Thanks to its natural DNA degradation function, DNase I is used to degrade NETs.