G3BP1 and melanoma: The relationship between SG formation and cell proliferation have been studied, depletion of G3BP1 decreases cell proliferation and anchorage‐independent growth in malignant melanoma cells[54]; knockdown of G3BP1 inhibits cell proliferation by regulating β‐catenin signaling, which downregulates proliferation‐related genes in breast cancer cells.[55] Consistently, we showed that G3BP1 KO cells reduced cell growth and abolished the effects of UTX in vitro and in vivo (Figure 8).