UTX mutations lacking TPR, JmjC, and/or IDR domain dramatically increase the level of DNA damage indicators RAD51 (DNA repair protein RAD51 homolog 1) and p‐γH2A.X, and cause cell apoptosis.[58] Here, we found cancer‐associated UTXD336G mutant promoted cell proliferation under ER stress (Figure 8A–D), affected UTX subcellular localization, promoted SGs formation (Figure 7). Here, KDM6A is linked to cancer.