KDM6A and cancer: As a well‐known H3K27me3 demethylase, UTX plays pivotal roles in cellular and developmental processes such as embryogenesis, hematopoiesis, and cancer.[21] A recent study indicated that UTX can phase separate in nuclei and regulates tumorigenesis.[19] Here, we report that cytoplasmic UTX plays a novel role in regulating SGs under ER stress, and also plays important roles in tumorigenesis (Figure 9E).