In LUAD, YAP is considered to play an important role in promoting tumor cell proliferation.[66] However, our study showed that the pro‐carcinogenic effect of ENH‐YAP is not cell‐autonomous or proliferation‐dependent; rather, ENH‐activated YAP promotes CCL5 transcription, which in turn promotes TAMs recruitment and M2 polarization. The gene discussed is CCL5; the disease is neoplasm.