In line with our findings, many studies have emphasized that YAP facilitates tumor progression by mediating heterologous communication between tumor cells and immune cells via paracrine‐acting factors.[67, 68, 69] The macrophage recruitment, as well as the M2 polarization‐promoting function of YAP in cancer, has also been well established.[70, 71, 72] The reason why ENH‐induced YAP activation does not affect cell proliferation may be that when ENH is knocked down or overexpressed, certain unknown molecules are also altered. This evidence concerns the gene PDLIM5 and neoplasm.