During this process, tumor cells and stromal cells such as macrophages are responsible for secreting pro‐angiogenic factors.[6] Up to now, a large number of pro‐angiogenic signals have been identified, among which the VEGF/ VEGFR signaling pathway is the most crucial one.[7, 8] Studies have shown that increased vessel density and elevated levels of VEGF, correlate with LUAD progression.[9, 10] Consequently, inhibiting angiogenesis can effectively inhibit LUAD development. Here, VEGFA is linked to neoplasm.