TAMs are important mediators that promote tumor angiogenesis by secreting pro‐angiogenic factors and facilitating the degradation of the perivascular extracellular matrix.[49, 50] Multiple oncology studies have confirmed that TAM counts are associated with MVD and that inhibiting TAMs recruitment significantly delays tumor progression.[51, 52] We found that ENH expression was positively correlated with multiple macrophage markers in LUAD specimens and that ENH overexpression in LUAD cells led to TAMs recruitment in vivo and in vitro. This evidence concerns the gene PDLIM5 and neoplasm.