KDR and infection: While it is widely used for skin inflammation control, long‐term systemic TKI usage also leads to multiple risks including cardiovascular disorder (e.g., hypertension, cardiotoxicity), immunosuppression and infection risks, as well as endocrine disruption, due to the fact that TKIs often impair VEGFR signaling, leading to increased blood pressure, which may result in long‐term cardiovascular complications, or chronic interference with immune‐related tyrosine kinases which could lead to immunosuppression, making individuals susceptible to infections or impaired wound healing [14].