For example, the use of antiplatelet agents (24.0 % vs. 59.6 %), beta-receptor blockers (24.7 % vs. 65.5 %), agents with an effect on the renin-angiotensin system (31.6 % vs. 69.0 %) and statins (18.5 % vs. 56.2 %) increased among patients with a self-reported lifetime diagnosis of CHD between 1997 – 1999 and 2008 – 2011 [47]. The gene discussed is REN; the disease is coronary artery disorder.