Furthermore, microglial activation, indicated by elevated expression of ionized calcium-binding adaptor molecule 1 (Iba1), contributes to neuroinflammation and synaptic dysfunction in schizophrenia (Drexhage et al., 2010; Prinz and Priller, 2014; Petrasch-Parwez et al., 2020). The gene discussed is AIF1; the disease is schizophrenia.