Regardless of the limitations, this study found three key variables that have a significant impact in participants’ knowledge regarding PrCa and screening as well as in their confidence, satisfaction, and self-efficacy when making decisions about whether to be screened or not: (1) having a family history of PrCa; (2) having had previous PSA screenings; and (3) understanding that although the PSA test and the DRE (Digital Rectal Exam) are both tests for early detection of prostate cancer, the PSA test is a blood test that should not be confused with the rectal examination. Here, KLK3 is linked to Familial prostate cancer.