In this cross-sectional study of AAM participants (40–69 years old) who completed demographic and baseline surveys, eight factors that may influence their knowledge about PrCa and their confidence, satisfaction, and self-efficacy when making decisions regarding having or not having a PSA screening test were identified: knowledge that PSA is a blood test; having had a PSA test in the past; having a family history of PrCa; type of health insurance; intention to screen; education; age; and clinical site. Here, KLK3 is linked to pure red-cell aplasia.