Ultimately, we identified ATP5ME, BEND3, C4orf48, ENTPD5, ITGA2, LPP, MACIR, PIK3R1, and SLC26A1 as the key prognostic genes to construct our model in the TCGA-PRAD cohort and verified their predictive performance in the validation cohorts. Here, NICOL1 is linked to prostate adenocarcinoma.