CD4 and bladder transitional cell carcinoma: In BLCA, DSN1 correlates positively with CD4+ Th1 cells (Fig. 6B), PDCD1, LAG3 (Fig. 6F), CXCR5 (Fig. 6H), and enhanced T-cell recruitment (Fig. 7A), indicative of a pro-inflammatory and immunoresponsive microenvironment.