MYC and cancer: High DSN1 expression in most cancer types was notably enriched in cell proliferation-related signaling pathways, such as MYC (which drives transcriptional activation of oncogenic targets) 33, mTORC1 (central to nutrient sensing and mitotic progression) 34, Mitotic spindle (regulating spindle formation), G2M (a critical phase of mitosis regulated by DNA damage response proteins) 35, and E2F (transcription factors controlling S-phase entry and cell cycle progression) 36 pathways (Fig. 5H and S5).