Importantly, DSN1 expression is closely associated with the development of various cancers, including colorectal cancer 7,8, hepatocellular carcinoma 9, breast cancer 10, gastric cancer 11, low-grade glioma 12, and osteosarcoma 13, by influencing key biological processes such as cell proliferation, apoptosis, migration, and invasion. The gene discussed is DSN1; the disease is cancer.