Finally, the study revealed the association of four key RBPs, MSI2, EZH2, NCL, and TERT, with the prognosis of colon cancer; however, the molecular mechanisms of the involvement of these RBPs in the pathogenesis of colon cancer have not yet been clarified, limiting the in-depthness and practicality of the study. Here, EZH2 is linked to colonic neoplasm.