In addition, DBF4B homodimer DBF4 was found to play a key role in hepatocellular carcinoma 10 and regulate the immune system at both transcriptional and post-transcriptional levels to modulate tumor progression 11, but for the role of DBF4B at the pan-cancer level remains unexplored further studies are needed. The gene discussed is DBF4B; the disease is hepatocellular carcinoma.