To further understand the difference in the expression of DBF4B in LIHC and normal tissues, we obtained specimens from 30 patients with hepatocellular carcinoma from the Department of Hepatobiliary Surgery of the First Affiliated Hospital of Guangxi Medical University and performed immunohistochemistry experiments, and semiquantitative scores were used for the evaluation of IHC. Here, DBF4B is linked to hepatocellular carcinoma.