STC2 and neoplasm: In addition, through TCGA, GSE100243, GSE74602, GSE143939, GSE89393, GSE144259 and GSE166427, it is found that STC2 is significantly expressed by tumor samples and the relative mRNA level of STC2 is significantly higher in stage IV, lymph node metastasis and organ metastasis samples (Figure 5A-5B).