ANXA5 and neoplasm: As shown in Figure 1D, the apoptosis rate (calculated as cell percentages with positive annexin-V staining and negative PI staining, as well as cell populations with positive annexin-V staining and positive PI staining) of hypoxic tumor cells treated by L-OHP was significantly lower than that of normoxic cells (p < 0.01 for DLD1 and p < 0.05 for LoVo).