For example, HIF-1α can directly transcriptionally activate the expression of multiple enzymes (e.g., Aldehyde Carboxylase A, Hexokinase, Lactate Dehydrogenase, etc.)and glucose transporters (e.g., GLUT1) involved in the glycolytic pathway to take up more glucose, accelerate cellular metabolism with energy production, and promote tumor growth 8. The gene discussed is HIF1A; the disease is neoplasm.