Down-regulation of microRNA-182 was found to inhibit RB by suppressing the PI3K/AKT pathway, while microRNA-153-3p was shown to impede RB cell growth and invasion through targeting the IGF1R/Raf/MEK and IGF1R/PI3K/AKT signaling pathways52,18. The gene discussed is MAP2K7; the disease is retinoblastoma.