In cancer, the role of PDE isoforms in cell survival and motility in different tumors, such as prostate (Henderson et al., 2014; Powers et al., 2015), breast (Nidhyanandan et al., 2015), leukemia (Dong et al., 2010) and colon (Ahmad et al., 2015) has been shown. The gene discussed is ALDH7A1; the disease is leukemia.