CBR3 and cancer: These genes include SLC transporters, which mediate DOX uptake into cancer cells [e.g., SLC22A16 (organic cation transporter)]; ABC transporters, which are involved in the efflux of DOX and contribute to drug resistance [e.g., ABCB1 (MDR1), ABCC1 (MRP1), and ABCG2 (BCRP)]; RABLP, which may influence the intracellular trafficking of DOX; and CBR enzymes [e.g., CBR1 and CBR3] or AKR1A, which are involved in DOX metabolism and detoxification.