Table 2 shows the top six SNPs considered risk variants for enhanced progression of HCC tumours at P < 5 × 10−5. These SNPs were located within the AK3, TRPM3 (2 SNPs), CDH4, LINC00504, and GRIN2D loci. In contrast, two markers in two genes (HPGD and RC3H2) were demonstrated to protect against disease progression at P < 5 × 10−5. The gene discussed is RC3H2; the disease is hepatocellular carcinoma.