Table 2 shows the top six SNPs considered risk variants for enhanced progression of HCC tumours at P < 5 × 10−5. These SNPs were located within the AK3, TRPM3 (2 SNPs), CDH4, LINC00504, and GRIN2D loci. In contrast, two markers in two genes (HPGD and RC3H2) were demonstrated to protect against disease progression at P < 5 × 10−5. This evidence concerns the gene RC3H2 and neoplasm.