In addition, NEDD4-1 mediates the degradation of Robo1, a tumor suppressor protein, facilitated by the transmembrane proline-rich γ-carboxyglutamic acid protein 4(PRRG4), which recruits NEDD4-1 to Robo1, thereby promoting BC metastasis (Zhang et al., 2020). The gene discussed is ROBO1; the disease is breast cancer.