Case presentations of progressive liver injury: One patient initially presented with mild liver injury (Grade 1) with cholestatic pattern that progressed to acute liver failure within 1 week, exhibiting terminal hepatocellular pattern changes with AST levels of 684 U/L, ALT >6000 U/L, ALP 161 U/L, and GGT 79 U/L, whereas TB and DB levels remained normal at 8.3 μmol/L and 5.3 μmol/L, respectively. The gene discussed is GPT; the disease is acute liver failure.