Finally, we further explored the expression of P53/SAT1/ALOX15 by PCR in patients diagnosed with squamous carcinoma only, and the results showed that the expression of P53 and SAT1 in SNSCC had a trend of elevation and ALOX15 had a trend of decreasing on the contrary compared with stage T4 patients in SNIP (Figure 3A–C). This evidence concerns the gene TP53 and squamous cell carcinoma.