Lin PL et al., analyzed the APC mutation from 165 CRC samples and found that miR-21-5p was associated with β-catenin phosphorylation at Ser552 via the PTEN/AKT axis and played a critical role in β-catenin nuclear translocation in APC-mutated cells, but not in APC-wild-type cells [314]. The gene discussed is PTEN; the disease is colorectal carcinoma.