TP53 and colorectal carcinoma: In addition, it was shown that the up-regulated miRNAs miR-183-5p and miR-21-5p and the down-regulated miRNAs miR-195-5p and miR-497-5p play important roles in the regulation of the mismatch repair mechanism as well as in the Wnt, RAS, MAPK, PI3K, TGF-β and p53 signaling pathways involved in the development and progression of CRC [74].