They also conducted analyses on HCT116, RKO and SW480 cells, demonstrating how miR-28-5p restoration altered the expression of CCND1 and HOXB3 and reduced the proliferation, migration and invasion of CRC cells, while miR-28-3p modulated the expression of NM23-H1 and increased the migration and invasion of CRC cells in vitro [70]. Here, HOXB3 is linked to colorectal carcinoma.