IL6 and neoplasm: With a positive feedback loop, CAF-produced miR-146a-5p and miR-155-5p target the suppressor of cytokine signaling 1 (SOCS1) and the zinc finger and BTB domain containing 2 (ZBTB2), promoting the production of inflammatory cytokines, including IL-6, TNF-α, TGF-β and CXCL12 favoring tumor progression [327].