Valeri N et al., demonstrated that the overexpression of miR-135b is associated with APC loss, the deregulation of the PTEN/PI3K pathway and the overexpression of SRC. The upregulation of miR-135b also promotes malignant transformation and tumor progression, especially in sporadic and inflammatory bowel disease-associated human CRC. The gene discussed is APC; the disease is colorectal carcinoma.