CDH1 and colorectal carcinoma: Other gene targeted by AP4 are the stemness markers LGR5 and CD44 as well as genes involved in EMT, such as SNAIL, E-cadherin/CDH1, OCLN, VIM, FN1 and claudins 1, 4 and 7. Hence, AP4 promotes EMT and increases the migration and invasion of CRC cells [361].