The data here reported strongly support the role of miRNAs in CRC development and progression since miRNAs regulate cancer cell proliferation, migration, and invasion by modulating several molecular pathways, including Wnt/β-catenin, PI3K-AKT, RAS, MAPK, TGF-β and p53 signaling. The gene discussed is TGFB1; the disease is colorectal carcinoma.