miR-145 plays a crucial role in cancer biology by directly targeting the pluripotency factors OCT4, SOX2, and KLF4. These factors are integral to the maintenance of stem cell pluripotency, which is also regulated by transcription factors like NANOG, SOX2, OCT4, KLF4, LIN28, and c-MYC. This evidence concerns the gene POU5F1 and cancer.