EGFR and colorectal carcinoma: For instance, HOX transcript antisense intergenic RNA (HOTAIR) negatively regulates the expression of miR-203a-3p, miR-545 and miR-218, leading to the up-regulation of their targets, such as β-catenin, groucho-related gene 5 (GRG5), epidermal growth factor receptor (EGFR), and vesicular pro-survival protein 1 (VOPP1), involved in the proliferation of CRC cells [[58], [59], [60]].