MAPKAPK5 and cancer: MK5 indirectly regulates MYC translation by activating the expression of miR-34b and miR-34c, which in turn bind the 3′UTR of MYC. Specifically, MK5 phosphorylates FoxO3a, thereby promoting its nuclear localization, inducing miR-34b/c expression and the inhibition of cancer cell proliferation [275].