CFL1 and neurodegenerative disease: As a result, a deeper understanding of the structural factors contributing to the stress-associated interaction of cofilin and actin is critical for defining the biological underpinnings of neurodegenerative diseases (Bamburg and Bernstein, 2016; Bamburg and Bloom, 2009; Davis et al., 2009; Davis et al., 2011; Maloney and Bamburg, 2007; Minamide et al., 2000).