CD4 and nonpapillary renal cell carcinoma: In contrast, ccRCC patients in the low-risk group had a highly infiltrated immune microenvironment characterized by the presence of CD4+ T cells, CD8+ T cells (TIMER method), B cells (CIBERSORT method), and M1 macrophages (Quantieq method), revealing that the low-MLRS group has stronger antitumor immune activity.