To characterize the immunologic landscape of ccRCC patients, we performed a comprehensive analysis of TME-related pathway scores using the ssGSEA algorithm and found that the infiltration levels of immune cells, such as CD4+ T cells, CD8+ T cells (TIMER method), B cells (CIBERSORT method), and M1 macrophages (Quantieq method), were significantly greater in patients with high MLRS than in those with low MLRS (Figure 5A), indicating immune activation status. Here, CD8A is linked to nonpapillary renal cell carcinoma.