CD8A and nonpapillary renal cell carcinoma: Furthermore, we observed that eight genes in the MLR were significantly correlated with tumor immune infiltrates, of which three upregulated genes (BIRC5, TPX2, and AGER) in ccRCC were positively correlated with CD8+ T cells, and the remaining five genes showed a negative correlation with Tregs, consistent with their prognostic results in ccRCC (Figure 5E).