TGFβ1 (Morikawa et al., 2016; Ark et al., 2018; Ong et al., 2021; Peng et al., 2022) and MMPs (Visse and Nagase, 2003; Bassiouni et al., 2021; Biel et al., 2024) are intricately linked in various biological processes, particularly in tissue remodeling and pathological conditions, such as cancer or fibrosis development. This evidence concerns the gene TGFB1 and cancer.