Other mutations prevalent in further studies in Brazil, such as BRCA1 c.3331_3334delCAAG, BRCA1 c.211A >G, BRCA2 c.2808_2811delACAA and BRCA2 c.5946ddelT, previously described, were not identified in this research.(21,22) The founder mutationTP53 c.1010G > A (p.R337H), associated to Li-Fraumeni Syndrome which has a high frequency in Southern and Southeastern regions, was neither identified.(23). This evidence concerns the gene BRCA2 and Li-Fraumeni syndrome.