TSC2 and Hereditary breast and ovarian cancer syndrome: The main altered genes were: BRCA1, BRCA2, associated with high penetrance and increased risk of Hereditary Breast and Ovarian Cancer syndrome (HBOC); ATM, PALB2, CHECK2, RAD5C, BRIP1 with moderate or low penetrance and other less common ones such as MLH1, MSH6, MSH2, PMS2, TSC2, ERCC5, FANCL.