Using GEPIA, we analyzed the Top 10 upregulated genes (PRSS2, AC093525.2, FAM157B, CST1, TBC1D3B, CXorf49B, C7orf55-LUC7L2, AC008758.3, AD000671.1, and CXorf49) and downregulated genes (CHURC1-FNTB, BLOC1S5-TXNDC5, TMEM189-UBE2V1, TBC1D3D, AC091304.1, AL136295.4, AL158066.1, GIMAP1-GIMAP5, MKX, and TRDN) in lung adenocarcinoma versus normal lung tissues (Table 2). The gene discussed is TRDN; the disease is lung adenocarcinoma.