DPYD and adenocarcinoma: He underwent an emergency right hemicolectomy, with histopathology confirming a pT4a pN1c R0, moderately differentiated adenocarcinoma of the ascending colon with a KRAS mutation but no NRAS and BRAF mutation, no dihydropyrimidine dehydrogenase (DPYD) variance, no microsatellite instability (MSI), and no neurotrophic tyrosine receptor kinase (NTRK).