(16) found that mice harboring a carboxyl-terminal 14 amino acid frame-shift mutation in THRB gene (TRβPV mouse) developed FTC spontaneously, and subsequent studies (15) indicated that TRβPV functioned as an oncogene in thyroid cancer via nucleus-initiated transcription as well as nongenomic signaling pathways. Here, THRB is linked to thyroid gland carcinoma.