CCL2 and thyroid gland disorder: A prospective study that evaluated peripheral blood cytokines and chemokines in patients with advanced malignancies undergoing ICI treatment demonstrated that elevated baseline serum levels of IL-1β, IL-2, and granulocyte-macrophage colony-stimulating factor (GM-CSF), along with early decreases in the levels of IL-8, granulocyte colony-stimulating factor (G-CSF), and monocyte chemoattractant protein-1 (MCP-1), were significantly correlated with the development of ICI-induced thyroiditis (89).