The comprehensive hormonal changes related to HPO-axis (GnRH, FSH, LH, estradiol, and progesterone), stress (CRH and cortisol), metabolism (leptin, ghrelin, and insulin), ovarian reserve (AMH), and inflammation/oxidative stress (IL-6, TNF-α, lipid peroxidation markers) will provide a more comprehensive perspective of FHA pathophysiology and facilitate direct comparions with POI and PCOS models, clarifying both shared and unique mechanisms. The gene discussed is GHRL; the disease is polycystic ovary syndrome.