The comprehensive hormonal changes related to HPO-axis (GnRH, FSH, LH, estradiol, and progesterone), stress (CRH and cortisol), metabolism (leptin, ghrelin, and insulin), ovarian reserve (AMH), and inflammation/oxidative stress (IL-6, TNF-α, lipid peroxidation markers) will provide a more comprehensive perspective of FHA pathophysiology and facilitate direct comparions with POI and PCOS models, clarifying both shared and unique mechanisms. This evidence concerns the gene GNRH1 and polycystic ovary syndrome.