For other conditions risk are varies ERCC6L2: The risk of AML/MDS is 10-30 % within 10 years24,25; SAMD9/SAMD9L: MDS is seen in 40-45 % of cases while AML is seen in 25-35 % of cases by 10 years of age.26,27. This evidence concerns the gene ERCC6L2 and acute myeloid leukemia.