Recent studies have shown that chemokines can influence CVD pathogenesis and progression by affecting autophagy, such as by blocking CXCR4 combined with its specific receptor CXCL12 through the PI3K/AKT/mTOR pathway to increase macrophage autophagy, alleviate atherosclerosis, and improve myocardial structure. Here, CXCL12 is linked to atherosclerosis.