Zero-valent iron nanoparticles (ZVI-NP) can target and enhance the degradation of nuclear factor-E2-related factor 2 (NRF2), inducing ferroptosis in lung cancer cells through the Fenton reaction (with MDA levels increasing exponentially), while polarizing M2-type tumor-associated macrophages (TAMs) to M1-type and reducing the infiltration of regulatory T cells (Tregs) by half. This evidence concerns the gene NFE2L2 and neoplasm.