BCL2 and neoplasm: Specifically, studies based on classical apoptosis-regulating proteins Bcl-2 and Bcl-xL aim to elucidate their mechanisms of regulating apoptosis, potentially through the formation of ionic conductive channels in synthetic lipid membranes by Bcl-2 and Bcl-xL (26–28), which subsequently modulate tumor cell apoptosis by altering intracellular Ca2+ concentrations (29).