CD8A and neoplasm: Conversely, the high-risk group’s association with elevated hypoxia, known to create an immunosuppressive environment, alongside reduced infiltration of cytotoxic T cells (like CD8 T cells and gamma delta T cells) and increased presence of M2 macrophages, indicates a potentially less ‘inflamed’ or more immunosuppressive tumor microenvironment, which is generally associated with poorer response to immunotherapy.