The serine biosynthesis pathway, which involves the enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH), is frequently upregulated in malignancies such as triple-negative breast cancer and melanoma (113, 114). The gene discussed is PSPH; the disease is triple-negative breast carcinoma.