Other contributing factors included hyperemesis gravidarum (10%, n.11), positive APCA (8%, n.9), Methylenetetrahydrofolate Reductase (MTHFR) mutation (4%, n.4), obesity (3%, n.3), and previous bariatric surgery (1%, n.1). The gene discussed is MTHFR; the disease is hyperemesis gravidarum.