Many women fall into the category of “metabolically healthy obesity” (with higher insulin sensitivity/absence of insulin resistance; more body fat but normal amounts of abdominal fat tissue; relatively less visceral and ectopic fat, primarily accumulating subcutaneously; normal metabolic indicators such as blood lipids, blood pressure, and blood glucose; and low levels of inflammation and oxidative stress), while men are more likely to experience metabolically unhealthy obesity (37). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.