Next, we tested the relevance of ANKH upregulation in senescent cell types that are relevant to age-related disease in mice, such as astrocytes (cognitive decline (Ogrodnik et al., 2021)), adipocytes (frailty (Xu et al., 2018) and type II diabetes (Palmer et al., 2019)), and myoblasts (frailty (Zhang et al., 2022)). This evidence concerns the gene ANKH and Mental deterioration.