The role of ANKH in age-related disease in humans has yet to be determined, but genome-wide analysis has associated the ANKH gene with a risk of developing AD (Bellenguez et al., 2022; Tesi et al., 2024), other forms of dementia (Katsumata et al., 2022), and type II diabetes (Nugent et al., 2020). This evidence concerns the gene ANKH and type 2 diabetes mellitus.