The HF-EA group demonstrated significant reductions in COX-2, mPGES-1 levels, and the PGF2α/PGE2 ratio (P < 0.01), a decrease in PGF2α levels (P < 0.05), and an increase in PGE2 (P < 0.05) and a significant increase in β-EP levels (P < 0.01). Here, PTGS2 is linked to hydrops fetalis.