CALCA and Sepsis: Intraperitoneal administration of peg-pro-DCD-C34S significantly reduced sepsis-induced systemic accumulation of G-CSF, IL-6, KC, MCP-1, MIP-2, and sTNFRI (Figure 4A), indicating that pro-DCD derivatives confer protection against sepsis by mitigating systemic inflammation of key sepsis surrogate biomarkers of experimental (24, 25) and clinical sepsis (26).