PRF1 and genital herpes: Instead, the spontaneous production of IFN-α, IFN-β, IFN-ω, IL-29, CXCL9, and perforin could imply that HSV-2 meningitis generates a more pronounced systemic innate immune response leading to stronger trained innate immunity (24), and epigenetic imprinting (25) than HSV-2 genital herpes.