In hypoxic gastric cancer cells, microRNA(miR)-301a-3p is enriched and transmitted between gastric cancer cells via exosomes, thereby establishing a synergistic positive feedback loop involving miR-301a-3p/PHD3/HIF-1α to facilitate the proliferation, invasion, migration, and epithelial-mesenchymal transition of gastric cancer cells (45). This evidence concerns the gene HIF1A and gastric cancer.